प्रसव पूर्व निदान के लिए हॉस्पिटल क्लिनिक के अनुसार प्रोटोकॉल के लिए प्रयुक्त।

Genetic Sonography App was created strictly for Fetal-Medicine specialists. All

calculations are used according to Hospital Clinic’s protocols for Prenatal Diagnosis

(http://medicinafetalbarcelona.org/clinica/images/protocolos/patologia__fetal/diagn%F3stico

%20prenatal.pdf). Calculations were obtained from the following articles:

Maternal Age Risk: Cuckle HS, Wald NJ, Thompson SG. Estimating a woman’s risk of having a pregnancy

associated with Down’s syndrome using her age and serum alpha-fetoprotein level. Br J Obstet Gynaecol.

1987;94(5):387-92.

First Trimester Markers: Illa M, Mula R, Arigita M, Grande M, Gonce A, Borobio V, Borrell A. Likehood

ratios to apply for Nasal Bone, Ductus Venosus and Tricuspid Flow at the 11-13 Weeks’ Scan in Down

Syndrome Screening. Fetal Diagn Ther 2013;34:116-120.

Second Trimester Markers: Agatholekus M, Chaveeva P, Poon LCY, Kosinski P, Nicolaides KH. Meta-analysis of

second-trimester markers for trisomy 21. Ultrasound Obstet Gynecol 2013;41:247-261.